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This is just amazing to read about. DNA from one mother split into another mother’s donor egg was injected with sperm from another money. Four healthy male monkeys were born, and this could prove to be a giant step in preventing diseases passed on to future generations. Read this interesting science piece from Science News…

http://www.sciencenews.org/view/generic/id/46732/title/Mitochondrial_DNA_replacement_successful_in_Rhesus_monkeys

Mitochondrial DNA replacement successful in Rhesus monkeys

New procedure may halt some serious inherited diseases, a study suggests

Scientists may have found a way to prevent the transfer of serious inherited mitochondrial diseases from mother to child. By shuttling DNA from an egg cell to a donor cell, the technique enabled the birth of four healthy Rhesus monkey males, researchers report online August 26 in Nature.

“We consider this a big achievement,” study coauthor Shoukhrat Mitalipov of the Oregon National Primate Research Center in Beaverton said in a news briefing August 25. “We believe that the technique can be applied very quickly to humans, and we believe it will work.”

Mitochondria, power-producing organelles in cells, carry their own DNA, distinct from the DNA held in cells’ nuclei. Healthy or otherwise, mitochondrial DNA is passed from mother to child. In recent years, researchers have identified more than 150 harmful mutations in mitochondrial DNA, some of which can cause serious and debilitating diseases (SN: 2/28/09, p. 20).

“This whole field of mitochondria medicine is very new,” says Douglas Wallace, a mitochondria expert at the University of California, Irvine. “It is a very important problem that’s been pretty much ignored. It affects lots of people, but we have very little to offer them.” Some estimates report that 1 in 6,000 people may have inherited a mitochondrial DNA disorder. Other estimates put the number higher, Wallace says.

A single cell can have thousands of copies of mitochondrial DNA. Usually, all of these copies are the same, healthy type, but occasionally a cell can have a mixture of normal and mutant mitochondrial DNA, a condition called heteroplasmy.

Heteroplasmy in an egg cell makes it nearly impossible to determine if a baby is going to inherit a severe mitochondrial disease, says Jo Poulton of the University of Oxford in England. “You can get quite a big range of how much mitochondrial DNA is transferred to children. There’s been a lot of debate on whether you can or can’t do genetic counseling” for these women, she says.

To get around the guesswork surrounding inherited mitochondrial diseases, the researchers took the mother’s mitochondrial DNA completely out of the picture. In the new work, researchers identified nuclear DNA in a mother’s egg cell by the DNA’s attachment to structures called spindles. Researchers removed the nuclear DNA (leaving the original mitochondrial DNA behind) and then put it into different egg cells lacking nuclear DNA but replete with healthy donor mitochondrial DNA. With the help of an inactive virus, the nuclear DNA fused into the donor cells.

Next, these modified egg cells were fertilized with donor sperm and implanted into Rhesus females to develop. Male twins, named Mito and Tracker, were born healthy, followed later by two more individual males, named Spindler and Spindy, from different mothers.

Researchers found no traces of the original egg cell’s mitochondrial DNA in the offspring, indicating that the process successfully prevented its transfer.

“I’m very pleased to see that, in nonhuman primates, this paper shows conceptually that this system might work,” Wallace comments.

The researchers used Rhesus monkey mothers with no mitochondrial DNA mutations because there are no established primate groups with such mutations, Mitalipov says. However, genetic signatures from the two cell groups—the mother and the egg donor—were distinct enough to tell apart easily, he adds.

Mitalipov and colleagues plan to monitor the monkeys as they age. “We’d like to see the growth and development of the offspring, to see if they have any abnormalities,” he says. Seeing how the mitochondrial DNA fares in subsequent generations will also be important, he adds. Doing that, though, will require female offspring, since mitochondria are passed on maternally. Mitalipov says they are now trying for a girl.

Many of the techniques used in the experiment are already in use at human fertility clinics, Mitalipov says, although the procedure as a whole will need to gain approval from the Food and Drug Administration before being used. The procedure, he says, “is offering real treatments to real patients.”

Others remain cautious. Wallace says that the virus used to integrate the nuclear DNA into a donor cell would need to be scrutinized for safety. The virus is “something FDA would look at very carefully,” before approving the procedure, he says. What’s more, no one knows what will happen as the monkeys get older. “They look normal now, but who knows what they’ll look like as they age,” Wallace says.

Poulton points out that techniques like this performed in animals might not reveal subtle defects, such as the mild hearing loss associated with some mitochondrial DNA mutations. “Doing it in an animal is quite a long way off from doing it in humans,” she says.

Now this is pretty amazing to watch. Definitely video you won’t see every day.

The people of U.S. Gulf Coast have felt unusually battered by big storms during the past few years. Now, it turns out their instincts are right.

A new report in the scientific journal Nature indicates that the last decade has seen, on average, more frequent hurricanes than any time in the last 1,000 years. The last period of similar activity occurred during the Medieval Warm Period.

The study is not definitive, but it is a unique piece of work that combines an analysis of sediment cores from inland lakes and tidal marshes with computer modeling and finds a “striking consistency” between the two, the authors suggest.

The use of sediment cores to place and date ancient storms — called “paeleotempestology” — is becoming an increasingly useful tool in the broader effort to try to reconstruct the history of hurricane activity in order to better predict a future potentially influenced by climate change.

Continue Reading:

http://abcnews.go.com/

Incubus – Aqueous Transmission

A nice YouTube video that has some relaxing pictures to go along with it…

Spider Monkeys Invent Medicated Body Scratcher

Jennifer Viegas, Discovery News

July 31, 2009 — Wild spider monkeys now have a new tool under their proverbial belt: a body scratcher that may release medicinal compounds, according to a study published in the latest issue of the journal Primates.

The study is the first to report this spider monkey scratcher. Lead author Stacy Lindshield told Discovery News that two other instances of the use of objects as tools by the social monkeys have been documented. Read the full story

Oil, one of the most important, valuable substances on the planet may form in an unexpected place, according to a new study — the crushing hot furnace of Earth’s mantle.

The petroleum we rely on to fuel our cars and heat our homes were formed over millions of years as ancient, dead algae and plankton were compressed in layers of sediment and heated. Because of this, oil companies know to look for new reserves in places that are, or once were shallow marine environments.

For decades, though, scientists have toyed with a tantalizing alternative theory of petroleum formation: What if chemical reactions between water and minerals deep in Earth’s mantle could send black gold bubbling up into the crust?

http://dsc.discovery.com/

Many people think the Colorado Grand Canyon is the largest in the world. However, the American Geography Committee announced in 1994 that it was in fact the Great Canyon of Yarlung Tsangpo (Brahmaputra) River in the Himalayas (Tibet) that claimed this title. The giant fissure descends to an astounding 5,382 metres at its deepest point and its length stretches for more than 496km. Another little-known claimant for the world’s biggest gorge is Fish River Canyon, a spectacular site in Namibia.

http://en.wikipedia.org/wiki/Yalu_Tsangpo_Canyon